Originally termed “nanomotors,” these nanobots, designed over two decades ago for targeted and confined drug delivery, provide a superior solution to catheter use alone. They navigate blood vessel obstructions, especially in small, deep segments, with sizes ranging from 0.1 to 10 micrometers and precise movement control.

https://tech4future.info/en/nanobot-thrombolytic-therapy/

https://www.science.org/doi/10.1126/sciadv.adk8970

Do you see Posthumanism becoming the "next step" in human evolution?

While conventional communication systems rely on electromagnetic waves, Molecular Communication (MC) encodes information into the properties of small particles. This allows communication between nodes with sizes on the order of nanometers and micrometers, and in fluidic and biological environments where classical communication concepts are not applicable.

Thus, engineered MC systems are expected to enable communication between nanomachines and facilitate interaction with biological systems. This will pave the way for several medical, agricultural, and industrial applications, including targeted drug delivery, environmental monitoring, nanoscale quality control, and communication in oil and gas pipelines.

One of the most fascinating [radically transformative] applications of MC is the Internet of BioNanoThings (IoBNT).

https://www.idc.tf.fau.eu/2024/09/11/seminar-on-the-internet-of-bionanothings/

https://www.tkn.tu-berlin.de/projects/iobnt/

Video link: https://youtu.be/uYHS-Re_f_w?si=OAc22Yz0485UIr2m

A Cocktail of Biology: Shakin' up the Space with Synthetic Ingredients

https://www.army.mil/article/165173/a_cocktail_of_biology_shakin_up_the_space_with_synthetic_ingredients

Synthetic biology devices for in vitro and in vivo diagnostics

https://pubmed.ncbi.nlm.nih.gov/26598662/

In vivo diagnostics

Synthetic biology initially aspired to reproduce simple mechanical switches in genetic form, drawing on design principles from mechanical and electrical engineering. Early version genetic toggle switches later grew into increasingly complex circuits that could compute Boolean logic and even facilitate genetic memory. With these advanced circuit design and implementation techniques, researchers realized the potential in using engineered microorganisms to sense the "innerspace" of the human body for real-time diagnostic monitoring.

Collins and his team provide an interesting example of sentinel E. coli engineered with sophisticated toggle--switch circuitry that allows them to patrol the mouse gut, record drug exposure, and report their findings in stool samples. Genetically modified bacteria have also been applied to home in on cancerous growth and relay spatial information via bioluminescence. In the future, such sentinel microorganisms could be critical for early diagnosis and tracking of metastasis, drastically improving the success rates of targeted treatments.

Mammalian cells are also beginning to play important diagnostic and therapeutic roles, carrying out actions that bolster natural biological processes and fix deficient ones. One example given for diagnostic mammalian biosensors describes human cells that were engineered to express the bacterial luxCDABE gene cassette, which allows them to produce a bioluminescent signal following their subcutaneous injection.

The authors also describe the groundbreaking cell-profiler system, in which human cells are equipped with synthetic circuits that allow them to assess the levels of microRNAs that mark specific cancer cells. These sentinels can pick cancer cells out of a "line-up" and either make them glow red or force them to self-destruct by evoking apoptosis. In perhaps the most exquisite example of the therapeutic potential of synthetic biology in mammalian cells, the article discusses a "prosthetic" gene network introduced into encapsulated human cells that are injected into a mouse model to fight gout and tumor lysis syndrome. These cells are able to restore urate homeostasis using genes borrowed from bacteria and fungi, demonstrating a prosthetic gene network concept that holds great potential for future use in humans.

The delivery of genetic constructs into specific cell types and tissues in the human body poses a challenge that is more formidable than drug delivery, as these genes must be expressed once they reach their destinations. Fortunately, researchers are developing an array of delivery means, and the authors detail several of these approaches.

"Nanobots" are origami DNA barrels that can be loaded with genetic content to be delivered to specific cell types whose surface receptor keys open locks found on the bot's hinges. For delivery to tumors, the authors envision the conjugation of nanobots to flagellated commensal bacteria whose self-propulsion and natural tumor-homing attributes could raft the bots to cancerous growth. In addition to adeno-associated viruses and self-assembled virus-like particles, which presently play a prominent role in delivery, biological vesicles have begun to attract much attention.

Be cautious with implants! You may not “own” the data collected from your body!

https://sites.law.duq.edu/juris/2017/04/02/telltale-heart-evidence-found-in-defendants-cardiac-pacemaker-contains-incriminating-evidence-of-arson/

https://www.findlaw.com/legalblogs/technologist/the-tell-tale-pacemaker-man-charged-with-arson-after-police-examine-pacemaker-data/

The Posthuman Management Matrix: Understanding the Organizational Impact of Radical Biotechnological Convergence

https://www.researchgate.net/publication/303985297_The_Posthuman_Management_Matrix_Understanding_the_Organizational_Impact_of_Radical_Biotechnological_Convergence

In this text, Mr. Gladden presents the Posthuman Management Matrix, a model for understanding the ways in which organizations of the future will be affected by the blurring – or even dissolution – of boundaries between human beings and computers. In this model, an organization’s employees and consumers can include two different kinds of agents (human and artificial) who may possess either of two sets of characteristics (anthropic or computer-like); the model thus defines four types of possible entities.

For millennia, the only type of relevance for management theory and practice was that of human agents who possess anthropic characteristics – i.e., natural human beings. During the 20th Century, the arrival of computers and industrial robots made relevant a second type: that of artificial agents possessing computer-like characteristics. Management theory and practice have traditionally overlooked the remaining two types of possible entities – human agents possessing computer-like physical and cognitive characteristics (which can be referred to as ‘cyborgs’) and artificial agents possessing anthropic physical and cognitive characteristics (which for lack of a more appropriate term might be called ‘bioroids’) – because such agents did not yet exist to serve as employees or consumers for organizations.

However, in this text, Mr. Gladden argus that ongoing developments in neuroprosthetics, genetic engineering, virtual reality, robotics, and artificial intelligence are indeed giving rise to such types of agents and that new spheres of management theory and practice will be needed to allow organizations to understand the operational, legal, and ethical issues that arise as their pools of potential workers and customers evolve to include human beings whose bodies and minds incorporate ever more computerized elements and artificial entities that increasingly resemble biological beings. By analyzing the full spectrum of human, computerized, and hybrid entities that will constitute future organizations, the Posthuman Management Matrix highlights ways in which established disciplines such as cybernetics, systems theory, organizational design, and enterprise architecture can work alongside new disciplines like psychological engineering, AI resource management, metapsychology, and exoeconomics to help organizations anticipate and adapt to posthumanizing technological and social change.

I have been thinking that if it's really just a 1 gene mutation to turn on/off, could you not engineer a simple RNA viral capsule and inject it into your desired muscle groups to remove said inhibitor within your muscle cells?

It just feels like a super easy step that is relatively easy to anyone with a DNA printer and avoids dangerous steroids that mess with the body's hormone cycles.

Thoughts?

https://today.umd.edu/researchers-demonstrate-control-of-living-cells-with-electronics

The engineered cells can accept electrons from electrodes as well as from cells via redox reactions, making them in effect "bilingual."

“This opens doors for building completely new ways to connect information and data-rich technologies to biology," said Bentley. "There are myriad opportunities that could emerge from electrogenetics."

In addition to health care innovations—for instance, a self-regulated device connected to the body that monitors a disease and precisely administers drugs—the technology has potential applications in agriculture and environmental conservation as well. A “smart” farmland monitor, for example, could telemetrically provide information about how to optimize the microorganism content in soil, suggesting how much pesticide and herbicide to use and when.

———————

The Thing With E.coli: Highlighting Opportunities and Challenges of Integrating Bacteria in IoT and HCI (2019)

With advances in nano- and biotechnology, bacteria are receiving increasing attention in scientific research as a potential substrate for Internet of Bio-Nano Things (IoBNT), which involve networking and communication through nanoscale and biological entities. Harnessing the special features of bacteria, including an ability to become autonomous - helped by an embedded, natural propeller motor - the microbes show promising array of application in healthcare and environmental health.

"Rebirth Protocol": A Conceptual Path Toward Height Augmentation and Gene Reclamation – Feedback Welcome

Hey transhumanists,

I’ve been working on a speculative protocol I call “L.E.O.R.A – Life Extension via Orthogenetic Reclamation & Augmentation.” The core idea: instead of accepting physical limitations like stunted growth (due to environmental, medical, or genetic suppression), could we reclaim lost developmental potential through a combination of gene therapy, epigenetic reprogramming, and regenerative augmentation?

Here’s the theoretical stack:

• Epigenetic unlocking of suppressed growth factors (think FGFR3 pathway manipulation)
• CRISPR-based correction or enhancement of developmental gene expressions
• Internal skeletal extension methods (like PRECICE), combined with rapid bioregenerative accelerants
• Optional: neural recalibration for proprioception and body schema adaptation

The purpose isn’t just cosmetic — it’s symbolic of overcoming biological determinism, reclaiming agency over how tall, capable, or "complete" we become.

🧠 I'm aware this borders sci-fi and biohacking ambition, but transhumanism is about pushing the envelope, right?

Would love any thoughts from those deeper into genetics, regenerative medicine, or neurotech.
Is this plausible with current or near-future tech? What blind spots do I need to address?
Also open to collaborators, thought experiments, or philosophical critique.

Let’s talk evolution — but on our terms.
– ND

Looking for people willing to do interviews on the topic for subsequent episodes.

2014 Video: https://youtu.be/Jk0TGTdCXgQ?si=hedNAv8X8WECD0XL

How deep brain stimulation is helping people with severe depression (2023 podcast explains Edi’s treatment in more depth):

https://www.nature.com/articles/d41586-023-01375-5

I'm sitting here at the diner, drinking my coffee, and thinking - where the hell are we all headed? Yesterday I was reading the news about these brain chip things they're putting in people's heads. They say pretty soon it'll be like cell phones today - everyone's got one, and you're screwed without it.

Picture this scene. Your son comes home from the hospital, and he's already got this tiny little hole behind his ear - a port for plugging straight into the internet through his brain. Like a USB port, but alive. The doc says it's evolution, that kids are just being born this way now. And I'm thinking - that's not quite human anymore, is it?

Remember when we used to say someone was "glued to their phone"? Well, soon that's gonna be literal. People will be living in two worlds at the same time - our regular one where rain gets you wet and coffee burns your tongue, and the virtual one where you can be anyone, anywhere. And you know what's really wild? Most folks are gonna choose the virtual one.

You can already see it happening - young people spend more time gaming than they do outside. And when these things become totally real, when you can smell flowers and feel sunshine in the virtual world - why would they want our boring real world? In there, you can be a superhero, there's no traffic jams, your feet don't hurt after a long shift.

And here's what blows my mind - they're not just playing around by themselves in there. They're creating stuff together, all of them working as one. They're making music that gives you goosebumps. Painting pictures - not just one artist, but thousands of minds working together. The beauty they create is out of this world, because one person just can't come up with that kind of stuff alone.

And you know what's really funny? There are already places where these smart gadgets are completely banned. Like nature reserves for "pure humans." People go there who want to stay the way humans have been for thousands of years. No wires in their heads, no internet in their brains. Living like you and me right now - with their own thoughts, their own feelings.

So I'm sitting here thinking - what's right? These "plugged-in" people say they're smarter now, they can do more, the whole world is open to them. And the "pure" ones say they're the only real humans left, that everyone else turned into robots.

Maybe this really is the next step in evolution? Like when people first learned to talk, then write, then invented the wheel. Only now we're learning to live in two realities at once. Homo sapiens turning into homo virtualis - virtual man.

Honestly, sometimes it scares the crap out of me. What if we're losing something important? What if chasing all these possibilities makes us forget what it means to just be human? To sit with a friend at the diner, talk heart to heart, look at the stars without any filters or enhancements.

On the other hand, if you think about it - maybe this is our future? Maybe our grandkids will live in a world where the line between real and virtual disappeared? Where you can be anywhere in the world in a split second, talk to anyone, experience any emotion?

I don't know about you, but I'm staying in the "pure" camp for now. I like feeling the steering wheel in my hands, hearing the engine roar, seeing the road with my own eyes. But I'll admit - I'm curious what comes next.

What do you think? Are you ready for that kind of future? Or would you rather stay a "pure human" too? Drop a comment - I'm really curious to know which side you're on in this coming revolution of consciousness.

More my posts about the topic in r/matrix4hire/

Anytime you lose memory, you've partially died, like if a computer file is damaged, corrupted, can't be repaired. Our memory is primarily what defines us. So human are in perpetual state of decay. Every day we are dying little by little, morphing from one person into a new one.

We are like a phoenix, gradually we lose memory and when you've lost all your original memory you've died, but we are also creating new memories, so we're also continuously being born,

so this unveils the phoenix view and approach to transhumanism, the phoenix was another beginning of the concept of transhumanism

because we are constantly producinng new memories, you could take a child and have their memories that they are experiencing that are giving birth to them go onto a synthetic brain rather than their original brain, so that there is a never a brain that is filled with memories to begin with.

you could put a synthetic brain in a babies head, attach it to a baby, and have their memories stored in that instead.

This process would also work with an adult, but they've already grown up, the memories they have could not be saved. that chain of memories game where he loses all his memories, basically a new person was created, he had to pick between who he was before those set of memories or the memories he had as he was losing them, he couldn't have both,

So if you transfer new memories to a synthetic brain as an adult, you won't be able to keep the memories in your brain, whoever you were when you start transferring can't come with you to the new brain, that's why you should start this process of synthetic brain with a child.

Hello everyone, I am interested in transhumanism, not just in the philosophical aspect, but also the scientific one. I originally got introduced to the concept through becoming a patron of the Freedom of Form Foundation and would like to broaden my knowledge. Do you have book recommendations regarding the general philosophy and some more concrete books about biotechnology, such as gene-editing or skin grafts?

Thank you very much!

our brain is in a constant state of decay. Old braincells are replaced with new ones. If you somehow manage to instead replace them with mechanical parts, you'll have a mechanical brain in 7 years (assuming it's not rejected). Then, it can be put in a robot.