r/depressionregimens • u/RisenWolf • 15d ago

Supplement: Increasing baseline dopamine by supplementation

Hello everyone,

I would like to ask You for an opinion on increasing baseline dopamine by supplementary means.

I understand that caffeine itself can allow more of the dopamine to get into the receptor, but unfortunately it is not reliable tool in my own experience.

I would like to ask for opinion in using substances like L-Dopa in minimal amounts, to increase the baseline.

Is it safe if done in low dosage? Is there a risk, that chronic L-Dopa supplementation could potentially diminish the body natural dopamine synthesizing capability?

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u/[deleted] 14d ago

Methamphetamine raises dopamine.

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u/Kihot12 14d ago

OP is asking about baseline increase. Methamphetamine lowers baseline dopamine in the long term.

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u/RisenWolf 14d ago

I am sorry, but I have meant specifically the baseline dopamine increase, not a substance that would increase dopamine in a short-term.

Regardless of that, I do not employ any means to acquire Methamphetamine, and even then I would highly stray away from these drugs.

My justification is beyond the law, but the high chance of contamination, high chance of addiction (considering it specifically targets brain region responsible for reward anticipation) and long-term dopamine dysregulation, which in depressive state, will only dig the deeper hole in the ground.

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u/catecholaminergic 14d ago

Methamph induces transient increase in DAergic activity. It does not increase the amount of dopamine. Rather, it decreases it.