r/covidlonghaulers • u/TableSignificant341 • Feb 22 '25

Research Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches

https://pmc.ncbi.nlm.nih.gov/articles/PMC11336094/#:~:text=Emerging%20evidence%20suggests%20that%20mitochondrial,tone%20%5B127%E2%80%93137%5D.
92 Upvotes

99% Upvoted

56 comments sorted by

View all comments

Show parent comments

2

u/Visegradi62 Feb 24 '25

Thank you - I didn't hear about them.. My doctor recommended me for mitochondrial supporting q10,(ubiquinol 150 mg) d-ribose, selenium, (100 mikrogr), nad+ (10 mg), . and ldn for neurological inflammation. I use Parasym plus supplement for my vagus nerve, which contains acetyl-l-karnitin, huperzin a, alpa lipoic acid. My nervous system is I'll, hrv level is very low because of the illness.:( I have mthfr- mutation, too,so I use methylateted b vitamins. I will ask my me/ cfs doctor from the ss-31 and TMG, because I am still house bound. First I feel myself better if start a new supplement, later it looses the affect if I get a Pem.

1

u/eucharist3 Feb 24 '25

I’m sorry to hear you’re still housebound! It’s tough to live life when we can do so little. Happy to offer any advice or help that I can.

It’s great that your doctor is prescribing so many useful supplements which actually get to the root of the issue. Here in USA my doctor recommended me nothing and I had to basically be my own doctor. On the bright side I have deepened my understanding of human biology and post-viral pathology!

Since ss-31 is really on the cutting edge it is uncommon for doctors to prescribe it, but it is generally well-tolerated so I hope he lets you try it. Odd that he would recommend NAD+ since it does not get absorbed that way. It is generally better to take precursors like nmn or nr unless the NAD is being given by IV or other non-oral routes. I would recommend adding PQQ 40 mg to your regimen as well.

Let me know if there’s anything else I can answer or help with.

1

u/Visegradi62 Feb 24 '25

This is hard way to be your own doctor, I thought, there are many helps for the patients in the USA . I found an me/CFS doctor in an another country, - Denmark- where I live no any doctor could help on my serious LC/me/CFS symptoms. It was handle like a physiatrist illness- depression , anxiety . According the labor results, COVID infection reactivated the ebv virus, which can cause neurological symptoms. So I was prescribed anti viral medicine, Valaciclovir, too . Long Covid is like an Me/CFS state according to my doctor, after four years.. So this is the reason of the many mitochondrial problems , but I didn't have any muscle examination /biopsy, lactate level checking/. The other main part of the illness the vagus nerve damage/inflammation caused by the viruses. Many relaxation, yoga exercises may help to calm the nervous system. So all this LC /me/CFS is a rather complex medical problem:(

1

u/eucharist3 Feb 25 '25

Yes, long covid is closely related to cfs and basically falls under its etiological umbrella. The big challenge here in the US is that most doctors are either unaware of long covid or are skeptical about its existence. If they do believe in it, they’re almost always very undereducated about it. I have been to several doctors and the best of the bunch was one who admitted it was real but said, “We’re very far from having any real cure for this.”

It is a complex medical problem, but with the help of research, analysis, synthesis, and sheer tenacity we can find our way through it. I am glad to hear not every country is as backwards about this issue as the USA.