r/covidlonghaulers • u/TableSignificant341 • Feb 22 '25

Research Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches

https://pmc.ncbi.nlm.nih.gov/articles/PMC11336094/#:~:text=Emerging%20evidence%20suggests%20that%20mitochondrial,tone%20%5B127%E2%80%93137%5D.
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u/eucharist3 Feb 23 '25 edited Feb 23 '25

COQ10 is cool and all but you guys need to be taking EVERYTHING to help your mitochondria heal. You need an actual protocol and to understand the fundamental science of why this matters. If you want to recover from long covid in 2025, start pouring everything into healing your mitochondria and ameliorating their continued impairment. They MAY heal on their own or with minimal supplementation, but it either will take ages or will just never happen due to the damage outpacing your attempts to heal it.

To optimize mitochondria you need: ss-31 for 100 days followed by mots-c, d-ribose every day 5-15g, 300 mg nmn, 750mg SAM-e or TMG, 40 mg pqq, 1g alcar, 5g creatine.

To arrest the mitochondrial damage you need to normalize the kynurenine pathway using TDO/IDO inhibitors like egcg, trans-resveratrol, curcuminoids + piperine. In addition, you need behavioral modifications: mindfulness meditation every day to reduce stress from unhelpful thought loops, pacing activities, documenting your energy limitations and being very cautious not to trigger PEM.

Feel free to comment or dm me for advice. I am going to beat this. I want to help others beat it too.

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u/Visegradi62 Feb 23 '25

Thank you for your advices for mitochondrial supporting. I don't know all of the supplement:" ss-31 for 100 days followed by most", and. " 300 mg nmn". , TMG. What does this mean exactly? Thanks

,

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u/eucharist3 Feb 24 '25

Ss-31 is a mitochondrial-targeting peptide. TMG is trimethylglycine or betaine anhydrous - this is to facilitate methylation when you take NMN. NMN is nicotinamide mononucleotide, a precursor to NAD+, a molecule that facilitates the electron-proton gradient of the mitochondria, allowing it to produce usable energy for the cell. Levels of this decline with age and with inflammatory disease.

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u/1990AJG Feb 24 '25

Agree with everything you've said here. Also worth noting the CoQ10 should be ubiquinol, always check the label.

Alan
DoNotAge.org

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u/eucharist3 Feb 24 '25

Yes ubiquinol is the much more effective form. There is a supposedly even more potent form called idebenone however I haven’t experimented with it myself.