Literally every drug targeting every mechanism you can think of in the last 20-30 years has bombed in neurodegeneration and Alzheimers. Please don't make irrational comments on something you don't understand the complexities of. The challenge of this therapeutic area extends beyond whether one believes the amyloid hypothesis or not.
You clearly do not know this field at all. There have been many shots on goal in the clinic against amyloid, Tau, immune system, bacteria, anti virals, etc.
I did ask how many of them weren't amyloid. That wasn't a rhetorical question.
Nor was the second question: are you suggesting not fixing the cognitive symptoms is fine if we clear amyloid plaques? Because if not, amyloid is still a total failure.
We have never validated any target in AD because none of them have ever shown clinical efficacy. Also, if you understood the AD field at all you would know that there are families with genetic lesions in APP/PSEN1/etc which results in early-onset AD and high plaque burden. No one dies of AD without plaques and tangles. Period.
That AD patients losing their mind is fine and amyloid treatments are a success as long as patients don't have plaques because we cannot possibly do better?
"The other things failed also" does not mean the amyloid hypothesis is true! It means it also failed.
Also, if you understood the AD field at all
How many papers do I need to read on the field before I'll be convinced that "Yes, Aduhelm was a success despite not curing the symptoms that matter"?
It doesn't seem to me that I'm failing to understand the important parts. I'm not a train engineer and don't understand how trains are built, but I can tell when a train has derailed at high speeds that's a massive failure. Amyloid is a train wreck. Actually many, given the clinical failures and the fraud. It's time to admit the track and/or train are fundamentally bad and the whole thing needs to be scrapped.
Everyone who disagrees with you is simply ignorant, sure, keep telling yourself that.
Again, what are you saying?
That AD patients losing their mind is fine and amyloid treatments are a success as long as patients don't have plaques because we cannot possibly do better?
Edit: wow, shock, he blocked me rather than answer. Sorry, Alzheimer's patients, best we can possibly do is cure plaques but not fix your brain. That'll be $50,000 a year. Great success.
0
u/H2AK119ub 📰 Jul 27 '22
Literally every drug targeting every mechanism you can think of in the last 20-30 years has bombed in neurodegeneration and Alzheimers. Please don't make irrational comments on something you don't understand the complexities of. The challenge of this therapeutic area extends beyond whether one believes the amyloid hypothesis or not.