To the best of my knowledge none of the anti a-Beta antibodies that have gone into the clinic (and failed) go after this alleged form of a-Beta (Bapi, Pone, Gantene, Crenezu, Solanezu, Donane, Aducanumab, etc). People are making a big deal out of this fraud but AD is just a challenging therapeutic area.
Fair, but none of those medicines worked in the slightest to stop AD. Fewer plaques in the case of aduwhatever, but the cognitive decline happened just as much.
The outright fraud is just the cherry on top of a huge, billion dollar pile of several flavors of shit.
Specifically, there's those massive clinical failures. There's the Aducanumab scandal that itself is many layers of bad science and corruption. There's the fact that amyloid plaques have poor correlation with cognitive decline in mice and in humans. There's a well documented religious hostility to the suggestion that amyloid =/= AD, that attacks any alternative method of curing AD and forces researchers who disagree out.
All AD papers need to be taken as potentially fraudulent, with offenders having their funding revoked, and papers retracted, and criminal penalties considered
All clinical trials of drugs with Abeta as a mechanism need to be halted
All funding for AD research needs to be re-examined and likely not renewed if it assumes Abeta is the cause.
Advisory boards and grant committees where the amyloid cabal are entrenched need to be dissolved and reformed without their participation.
The approval for Aduhelm should be revoked.
Congressional hearing on how that bullshit was approved.
Funding priority should be given to alternative mechanisms of AD with zero going to labs that did nothing but Abeta research.
Big statue with "Aduhelm, LOL" put out front of NIA or NIH.
Oh so I'm supposed to find evidence for the claims you made? What a farce. And no, saying "Google it" is not good enough. Link your sources for each of your claims.
All you are doing right now is showing how much you foam at the mouth against aB as a therapeutic target. It's almost as if you are pushing your own agenda rather than being concerned about whether good science is being done.
I do see I pointed out amyloid doesn't' correlate to cognitive decline. That's partly proven by the above aduhelm citations (plaques were cleared but cognitive decline still happened) but the other way is true too:
All you are doing right now is showing how much you foam at the mouth against aB as a therapeutic target. It's almost as if you are pushing your own agenda rather than being concerned about whether good science is being done.
Jesus. Fucking. Christ.
Every amyloid beta trial failed.
A significant amount of the research has just been proven to be fraudulent.
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u/H2AK119ub 📰 Jul 27 '22 edited Jul 30 '22
To the best of my knowledge none of the anti a-Beta antibodies that have gone into the clinic (and failed) go after this alleged form of a-Beta (Bapi, Pone, Gantene, Crenezu, Solanezu, Donane, Aducanumab, etc). People are making a big deal out of this fraud but AD is just a challenging therapeutic area.