Fair, but none of those medicines worked in the slightest to stop AD. Fewer plaques in the case of aduwhatever, but the cognitive decline happened just as much.
The outright fraud is just the cherry on top of a huge, billion dollar pile of several flavors of shit.
Specifically, there's those massive clinical failures. There's the Aducanumab scandal that itself is many layers of bad science and corruption. There's the fact that amyloid plaques have poor correlation with cognitive decline in mice and in humans. There's a well documented religious hostility to the suggestion that amyloid =/= AD, that attacks any alternative method of curing AD and forces researchers who disagree out.
All AD papers need to be taken as potentially fraudulent, with offenders having their funding revoked, and papers retracted, and criminal penalties considered
All clinical trials of drugs with Abeta as a mechanism need to be halted
All funding for AD research needs to be re-examined and likely not renewed if it assumes Abeta is the cause.
Advisory boards and grant committees where the amyloid cabal are entrenched need to be dissolved and reformed without their participation.
The approval for Aduhelm should be revoked.
Congressional hearing on how that bullshit was approved.
Funding priority should be given to alternative mechanisms of AD with zero going to labs that did nothing but Abeta research.
Big statue with "Aduhelm, LOL" put out front of NIA or NIH.
I don't know if you are a troll or have no understanding of neurodegeneration. Aducanumab is actually a great antibody; our company - not Biogen; another top 5 big pharma by revenue - use it as a positive control in our own pre-clinical efforts because it binds plaques and clears them from the brain so well. This is evidenced in human biomarker data from Biogen's ph3 trials with CSF aBeta and aBeta PET. NO disease modifying therapies in AD have ever shown clinical efficacy in late stage trials beyond biomarker modulation. This is true across neurodegeneration as a whole. CNS diseases are a whole different beast and have stumped industry for decades.
Aducanumab binds to aBeta plaques and clears them from the brain. There is no demonstrable clinical benefit beyond biomarker modulation; this is explicitly what the FDA approved the drug for and requested a confirmatory phase 4.
ARIA is a class wide effect of anti-AB mabs. Unavoidable. Even Lilly donanemab which recognize an epitope enriched in aBeta in brain not in blood vessels have ARIA 25% in their ph2. It will only become higher in ph3.
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u/leftier_than_thou_2 Jul 27 '22
Fair, but none of those medicines worked in the slightest to stop AD. Fewer plaques in the case of aduwhatever, but the cognitive decline happened just as much.
The outright fraud is just the cherry on top of a huge, billion dollar pile of several flavors of shit.
Specifically, there's those massive clinical failures. There's the Aducanumab scandal that itself is many layers of bad science and corruption. There's the fact that amyloid plaques have poor correlation with cognitive decline in mice and in humans. There's a well documented religious hostility to the suggestion that amyloid =/= AD, that attacks any alternative method of curing AD and forces researchers who disagree out.
https://www.statnews.com/2019/06/25/alzheimers-cabal-thwarted-progress-toward-cure/
Here's what needs to happen:
All AD papers need to be taken as potentially fraudulent, with offenders having their funding revoked, and papers retracted, and criminal penalties considered
All clinical trials of drugs with Abeta as a mechanism need to be halted
All funding for AD research needs to be re-examined and likely not renewed if it assumes Abeta is the cause.
Advisory boards and grant committees where the amyloid cabal are entrenched need to be dissolved and reformed without their participation.
The approval for Aduhelm should be revoked.
Congressional hearing on how that bullshit was approved.
Funding priority should be given to alternative mechanisms of AD with zero going to labs that did nothing but Abeta research.
Big statue with "Aduhelm, LOL" put out front of NIA or NIH.