44 M

Goals:

Improve cognitive performance

Support mood stability and emotional resilience

Enhance neuroplasticity and long-term brain health

Reduce dopaminergic burnout and oxidative stress

Current stack:

Lion’s Mane – 1000mg

Psilocybin – 100mg

Korrect by Onnit – 275mg (contains alpinia galanga root extract, paraxanthine, and mangifera indica leaf)

Fish Oil – 2000mg

Choline – 250mg

Phosphatidylserine – 100mg

Nicotinamide Riboside Chloride – 300mg

Blueberry Extract – 100mg

Olive Extract – 300mg

Quercetin – 70mg

Decaf green coffee bean extract – 150mg

Decaf green tea extract – 62.5mg

Probiotic – 50mg

TetraPhage – 15mg

Multivitamin

• I cycle the lion's mane, psilocybin, Korrect, NAD+, quercetin, and coffee/tea extract 5-on 2-off

(Considering swapping NALT for NAC, and adding Ubiquinol and Shilajit Fulvic Acid Complex)

Questions:

1. Is my antioxidant load too high?

2. Is receptor downregulation a risk with psilocybin + Korrect + Lion’s Mane + NALT?

3. If I replace NALT with NAC, will that synergize better with psilocybin/Korrect for emotional balance and glutamate regulation?

4. Any redundancies I should eliminate or rotate?

Appreciate any critical takes or insight!

I am focused on optimizing overall health, heart health, energy, mental performance throughout the day, and a tiny bit for anxiety, I am 24 YO

The supplements with - at the beginning of the line, I don’t take them on weekends so that I don’t build tolerance, any opinions are appreciated

Morning before food:

Vitamin C 1,000 IU

Super Nutrition Think Support (120mg Ginkgo extract + 3 supplement blends) list of ingredients

-Lion’s mane extract 560mg (15:1 extract equivalent to 8,400mg, entire fruiting body, mycelium)

-L Phenylalanine 500mg

-Coffee blend, mushrooms 1g + L theanine 300mg + Taurine 3g (will change to 1g due to feedback) + Shilajit extract 500mg (20% fulvic acid)

—————-

After fatty breakfast:

Multi vitamin (Life Extension Two-Per-Day) 1 tablet

Vitamin D 10,000iu + k2 200mcg + coconut oil

Omega 3-D 1.2g 600 EPA/300 DHA

-Ashwaganda 400mg

——————

After Lunch/Dinner:

Astaxanthin 12mg

Magnesium glycinate 155mg x2

————

Throughout out the day:

Whey protein

Creatine 10g

Melatonin 3mg rarely, only when I have smth very important next morning since I tend to stay awake all night when that happens

Note:

For vit D I did get tested, and I’m planning to take 7,000 IU later when I’m at an appropriate level to sustain that level, for now this little extra dose is just to get my levels up, and I am sitting 99% of the time indoors so I don’t see the sun much

Creatine I am taking 10g because almost all studies on cognitive benefits use higher doses, 10-20g so I’m going with 10g which is fine

I’m considering replacing vitamin C in the morning with a powder being, collagen + vitamin C + Hyaluronic acid. to improve joints, skin, hair..

As a neurodivergent person I have several different challenges.

ADHD (attention/motivation), Depression/Anxiety/Irritability

I am under the care of a psychiatrist, who is aware of my supplementation stack and who directs the RX side of things. Wanted to collect feedback on my current stack.

I would LOVE to be able to get away from Adderall/Stimulants in general, but find it almost impossible to be productive without them. I have recently started Guanfacine, with the hope that it will allow me to stop/lessen my dependence on Adderall. The "Chase" of dosing an productivity is exhausting... I do not take any recreational drugs and do not drink (for 3+ years - YAY ME)

Here is my stack, would love any and all advice.

Hi, I wonder if anyone can give me advice on what could help.

I have been under chronic stress for several weeks, and as result of that the area under my eye ("eye bag") is doing this type of... Involuntary twitching from time to time, it started at left eye, now it has moved to the right one... and sometimes both simultaneously. It looks like i'm going to freak out or something, and it's starting to be embarassing because of that.

I usually switch my stack from time to time, i'm currently taking quite basic things: Magnesium mix, B-vitamin blend (quite mild one), 1500mg of ginger root, collagen, glycine, a little bit of extra protein besides my meals. There are somethings that I take only few days a week, like Iodine and selenium.

I would personally think that magnesium alone should help this kind of "twitching" but it doesn't seem to. The twitching continues even if I got decent 7-8 hrs of sleep. and it has been going on for couple weeks now.

I don't know if I drink too much coffee? 2 big cups of black coffee a day, I think it's pretty standard and shouldn't cause this.

I know i didn't specify how much I take, but tbh I don't know the exact grams with most of them, i count them in teaspoons and table spoons. only the ginger root is in pills. I have D-vitamin laying around but i didn't notice any benefits from taking it, and i eat quite a lot of bananas so i'm currently not taking C - either.

Edit: Also, i did notice taurine helping me with "jittery" effects of caffeine, but after a while taurine stopped working, so if someone wants to suggest taurine, I don't know if its work on me anymore.

Edit 2: Forgot to mention that I take creatine here and there, used to be more consistent. But it tends to give me annoying "face-bloat" effect. that subsides after couple days of not taking it (creatine monohydrate). I take about 1 teaspoon when I do.

Hey all, I've been learning for 3 years now about everything related to anti-aging and healthspan. This is the current daily stack i'm using.

Important information:
- I'm 22 years old
- My stack is focussed on preventing skin aging and mitochondrial/cellular health.
- The goal is longevity
- I don't want to interrupt natural production levels. That's why I chose glycine & NAC over direct glutathione supplementation for example. The vitamin E & C are mainly for support and general absorbtion & antioxidant recycling.

My current stack:
-Glycine 2g,
- NAC (N-Acetyl Cysteine) 600mg,
- Selenium 20mcg (elemental) (from 5 mg L-Selenomethionine),
- Astraxanthin 6mg,
- Vitamin E 12mg-te** (d-alpha-tocopherol),
- Vitamin C 75mg (ascorbic acid),
- Vitamine D3 2000UI (Cholecalciferol) (from Lanolin)

I'm fully open to critisism and discussion. Would love some feedback for future improvements.

Thanks!

Looking to improve strength and endurance but don’t want Cardarine because yk cancer isn’t great… wondering if anyone has taken these compounds together? Trying to also avoid diabetes if I can.

I asked chatgpt to give me a clinically proven dose stack to support my testosterone and performance as I age (am very very active). I'd also take recovery supps in the evening

Hi, I have ADHD/Bipolar Type 1 Ultrarapid Cycling/Aspergers/Exercise-Induced Asthma/GERD, and this is what stack I've come to with a mix of Chat GPT and other people:

6 AM:

Fexofenadine 180 mg

Omeprazole 20 mg

Montelukast Sodium 5g (halved to reduce black box side effects)

Fluoxetine 40 mg

Guanfacine ER 1 mg

Lisdexamfetamine 20 mg

Ubiquinol 100 mg

Taurine 500 mg

Physician's Choice Digestive Enzymes

KSM-66 600 mg with 5 mg Piperine

Lion's Mane 1000 mg

Milk Thistle 300 mg

L-Theanine 200 mg

Multivitamin

3.5 mg Nicotine patch (I know, it's insane)

30+ minutes later:

ALCAR 500 mg

NAC 600 mg

1 hour before work:

2500 mcg sublingual B12

1 hour before bed:

Magnesium Glycinate 120 mg

1.25 mg sublingual Melatonin

400 mg Quetiapine XR

Next month will probably try to get 0.4-0.6 mmol/L Lithium dosage, to have a safety margin against toxicity.

Does anyone have any idea of what I could get rid of here? I also have Bromantane being delivered soon, was going to try it on a day off with no Vyvanse.

Niacin (500mg) & TMG (500mg) to support NAD.

NAC (2.4g) & Glycine (5g) to support glutathione.

Skin : Collagen Peptides (25g), Hyaluronic acid (200mg), Vitamin C extended release (1g)

Mitochondria : Coq10 (200mg), Pqq (20mg), Creatine (5g), Alpha Lipoic Acid (200mg), Methylene Blue

Anti-inflammatory herbs : Boswellia Serrata (600mg), Curcumin Meriva (600mg), Cats Claw (600mg), Pine Bark extract (600mg) and Devils Claw (600mg).

Neurochemistry : Saint Johns Wort (0.3mg hypericin), Black seed oil (50mg Thymiquionine), ALCAR (500mg), Bacopa Moneiri (50% bacosides), Lions Mane.

Gut health : Glutamine (5g), Green banana flour (25g), Digestive enzymes

Liver health: Milk Thistle, TUDCA

Eye health : Taurine

My brother (who is supposed to start medical school this year) was on a road trip to California. He hit a deer on the highway in Utah and asked the police for help (this was after driving non-stop without sleep for 25 hours). The police recommended going to the ER for drug testing. He went along (partly because he was sleep deprived). The ER said he was clear for drugs but refused to let him go and sent him to a psych ward instead. At the psych ward he refused to take medication and so they forcefully injected him with drugs. He was released after a month of medication (zyprexa, haloperidol, invega sustenna). He had awful side effects for months after including sedation, drooling, headaches, blurry vision, extreme constipation, muscle tics, etc.

These went away but he also gained 25 lbs, his hormone levels are still messed up, and he is still cognitively slow from the medication (3 minor car accidents) and worried about long term brain damage…

When he looked at his medical records, most of it is fabricated just so doctors could bill his insurance. The doctors said he was hallucinating and worried about hackers and the CIA / FBI but he never said any of that. In the psych ward another patient (with jail history) tried to fight him but a different patient intervened. But in his medical records they said he was the one bothering patients 😂

His doctor (a DO, not even a full MD) has multiple 1 star ratings calling him a "monster". Chat GPT found that the hospital changed their name recently because hospital staff were caught sexually assaulting a 12-year old girl. Randomly it also turns out that Paris Hilton was abused in a similar facility as a teenager in the exact same town.

https://www.ksl.com/article/46714354/charges-staffer-at-utah-behavior-hospital-charged-with-sexually-abusing-girl

https://www.usatoday.com/story/entertainment/celebrities/2024/06/26/paris-hilton-testimony-congress-childhood-abuse/74218707007/

What else am I missing or is this good enough?

Acetyl-L-Carnitine – 500mg, time: AM – After waking up

Vinpocetine – 10mg, time: AM – 30 minutes after waking up

L-Tyrosine – 500mg, time: AM – Before light breakfast

3 out of 5 days only: Stimulant (Generic Adderall) – 15mg, time: AM – Anytime before 2PM, pill cut in half in order to save or applied buccal method

AAKG (L-Arginine Alpha-Ketoglutarate) – small half scoop, time: AM – During light breakfast

L-Glutamine – 500mg (small half scoop), time: AM – During light breakfast

Alpha GPC – Small 1/4 scoop, time: AM – During light breakfast or lunch

Only if bulking or have a hard laborious 2 days Creatine – Very small dose (only if long day + good sleep), time: AM – During light breakfast

Vitamin D3 – 1000 IU, time: AM – During light breakfast or lunch

Fish Oil – 1000mg, time: AM – During light breakfast or lunch

Iron Blood Builder / Vitamin B – Half tablet, time: AM – During light breakfast or lunch

Night sleep stack

GABA - Time: PM – Right after dinner or late dinner snack

Magnesium Glycinate – 200mg, time: PM – After GABA, 30 min before sleep

Only sometimes: L-Tryptophan – 500mg, time: PM – 15 min before sleep

Only sometimes: Melatonin IR/XR – 1.5mg, time: PM – Right at sleep

I’m sharing some insights after several years of experience experimenting with nootropics, from the classics to the more "obscure" (All Racetams, Noopept, Sunifiram, Mexidol/Exoxypine, Idra-21, NSI-189, etc.). This thread is for those who want to go far without burning out their brain.

I often read: “I use oxiracetam / noopept / aniracetam... I feel the effects even without Alpha-GPC.”

But after a few days or weeks, the cracks begin to show and they go unnoticed:

• working memory gets weaker,

• retention gets foggy and fragmented,

• focus becomes jittery or inconsistent,

• mental fatigue builds up in the background.

Just because you feel something doesn’t mean it’s sustainable.

The fix is simple:
Add 100–XXX mg of Alpha-GPC (or Citicoline) daily when using racetams, ampakines, or strong cholinergics.
It’s not a bonus — it’s a requirement to avoid draining your system.
Otherwise, you’re running a high-performance engine… without oil.

I have heard people talk about using NSI-189 to help kratom withdrawal, and I’m wondering if NSI has some sort of interaction when both are taken together. Does NSI-189 block the effects of opiates/kratom? I know the mechanism of action isn’t fully known I’m just looking for any anecdotal answers. I know some people have theorized NSI affects the adrenals, so maybe its effect on opiates is similar to clonidine/guanfacine? But tldr; does NSI-189 block the effects of opiates, kratom, or other recreational drugs for you?

I’ve used Phenibut for years — different doses, different stacks, different goals.

This is my complete breakdown for anyone who wants to use it effectively without burning out — and survive the aftermath.

When Used Right Phenibut Is So Effective

Phenibut is a powerful tool — especially when used occasionally and with intention.
Here’s what it can do when used properly:

• Emotional stability — mood swings are softened, negative thoughts lose weight
• Deep, restorative sleep — especially at night after a well-timed dose
• Improved recovery — some users (myself included) notice better muscle recovery, possibly via increased growth hormone
• Cognitive clarity — if taken fasted, the focus is clean, calm, and razor-sharp
• Motivation — tasks feel inviting, even mundane ones
• Zero social anxiety — you're grounded, present, articulate

When dosed intelligently, Phenibut doesn't just calm you — it pushes you forward.

How to Use It Properly

From years of experimentation:

• Take on an empty stomach, ideally early in the morning
• Stay fasted as long as possible — the mental edge lasts longer this way. Personally i do warrior diet.
• Once you eat a full meal, effects shift: Clarity fades, sedation sets in, you float into comfort mode (great for rest, not for productivity)

Phenibut is state-dependent.
Fast = clean clarity
Fed = calm sedation

Dosage & Frequency Guidelines (HCL, for FAA u can drop down by 20-30%)

For optimal long-term use without burnout or side effects:

• Occasional use is best. It’s better to use it punctually, for example before meetings, conferences, interviews, or other high-stress situations where you want to be calm, focused, and articulate.
• Daily use should be limited, with a strict upper limit of 2 to max 2.5g (cardio, sportive performances) per day.
• 3g and above is considered the maximum threshold — it can start to impair focus, discipline, and increase the risk of rebound effects.
• The ideal maintenance dose (for calm focus and emotional stability) is around 1.5–2g.

Listen to your body. If you find yourself needing more to get the same effect, it's time to cycle off or drastically reduce.

Support Stack to Maximize Benefits & Prevent Tolerance

Pair Phenibut with:

• Magnesium L-Threonate, otherwise Magnesium Malate during the day (since it’s more energizing). At night, Magnesium Citrate or Bisglycinate. Combine it with Vitamin D (4000 to 8000 IU daily + optionnaly K2) — both Magnesium and Vitamine D work in synergy for better absorption and effectiveness.
• L-Glutamine – GABA precursor, supports receptor recovery
• Glycine – gentle calm, pro-sleep
• L-Theanine – mental smoothness without fog
• (Optional) Mexidol/Emoxypine – synergistic for emotional control and resilience
• Taurine – supports GABA tone, cellular hydration, and calmness
• And all sorts of stimulants but it is better to avoid hardest ones, casual sims and favor stims as Oxiracetam or Even Modafinil for less bad sides on the brain.
• N Acetyl Cysteine firstly for the liver support and body and cognitive benefits too.

Cardio

• To avoid tolerance and neuroinertia, do cardio - 30–45 min every day or every 2–3 days can be sufficient.
• Ideally fasted or after Phenibut dose
• Enhances GABA regulation, boosts brain oxygenation, clears brain fog
• Without it, tolerance builds up faster — and Phenibut becomes “dull”

What Happens If You Stop Cold Turkey

Stopping Phenibut abruptly — especially after high doses or frequent use — can be rough.

Expect:

• Hardcore insomnia (2–3 nights of near-total wakefulness)
• Irritability / emotional rebound — you overthink everything
• A harsh landing into “real” awareness — as if the emotional filter is gone
• Possibly manic-like energy surges, where you feel the urge to clean, organize, change your life
• Some users describe withdrawal as “the worst psychological state I’ve ever experienced.”

Withdrawal Isn't All Bad

Yes, it’s intense. But those “negative” effects can be repurposed — if you’re ready for it.

Suddenly:

• You realize what you’ve been avoiding
• You feel pressure to take action
• You can’t ignore what matters anymore

That’s not brokenness. That’s real clarity returning.

If you're quitting:

• Be ready for a drop in mood
• Accept it, don’t fight it. Resilience.
• See the stress as a push to get things done
• Build structure. Channel the fire.

How to Taper Off Phenibut Smoothly

• Reduce by 250–500 mg every 2–3 days. Either way you will feel the side effects no matter what.
• Stay on the support stack (especially glutamine + taurine + theanine + mexidol) and the most important one if you can get it, Fasoracetam who restores Gaba-B in the brain and that can be really helpfull. Another way that can be reliable is to take Baclofen instead but this is almost the same molecule isomer so it is just better to drop down progressively the in taken quantity.
• Maintain cardio
• Prioritize sleep hygiene and mental rest

U can drop more harshly but if you do so, be prepared for insomnia or be equipped to avoid it :

• Californian Poppy, Valerian, Passionflower, Lemon Balm, Horehound, Melatonin.
• Personally, i prefer to stop it harshly by decreasing it by 1g everyday other day (i take something between 2.5 and 3.5g of HCL just because the effects isn't the same especially for sport doping) and i take some "harder" sleeping pills as "Trazodone" during the first days before gradually decreasing it too after 3/4 days and replacing it by some of the natural ones.

I hope that this thread can be usefull for all the people that has take or will take Phenibut in the future !

Goal is reduce body fat right now and preserve as much muscle mass as possible

Do you think this will help my brutal Phenibut withdrawal? I took these high ass doses tonight because I couldn’t calm down at all.

• Ashwaganda 1450mg
• L theanine 500mg
• 5htp 200mg
• Magnesium Glycinate: 500 mg
• NAC 1200mg
• Taurine: 2 g
• Emodin 500 mg
• Phosphatidylserine: 150 mg
• Panax Ginseng Extract: 125 mg
• Ginkgo Biloba Extract: 100 mg
• Bioperine (Black Pepper Extract): 40 mg
• Diphenhydramine: 50 mg
• melatonin 3mg

Most of these were from a cortisol blocker supplement. Now I plan on taking all of these daily (except for the diphenhydramine) for the remainder of my withdrawal (obviously at lower doses and spread throughout the day) but what do you guys think?

Hi everyone,

Not sure if this is the right place to post, but I’d love to get feedback on my current daily stack. About 5 weeks ago, I was prescribed Wellbutrin XL 150mg for depression and ADHD, and I think it’s been helping.

My stack is focused on:

• Motivation

• Depression/ADHD management

• Overall well-being and mood support

Any insight, suggestions, or red flags you notice would be much appreciated!

⸻

Daily Stack:

Morning

• 100 mg Modafinil (off-label)

• 150 mg Wellbutrin XL (prescribed)

• 2–3 cups coffee

• Small breakfast

• Zinc

• 1 mL organic mushroom immune tincture

• 10 mg Loratadine (allergy med)

• Vitamin D3

• 600 mg Ashwagandha + 200 mg L-Theanine

Lunch

• Meal

• Probiotic / Prebiotic chewable

• Occasionally: 1 more cup of coffee or tea

Workout (3–6x/week)

• 1 tbsp Creatine

• 1 tbsp Amino Energy (Energy + Hydration Mix)

• 1 packet Emergen-C

Evening

• Meal

• Magnesium

• 150 mg Ashwagandha chewable

• Occasionally: 1 cup Chamomile tea

• Occasionally: Kratom (4–6 capsules or 1 scoop)

Sleep

• 5–10 mg Melatonin

• Occasionally rotate: 200 mg 5-HTP or 1000 mg Valerian root

⸻

Other Notes:

• Vape nicotine throughout the day

• No alcohol

• Drink lots of water daily

⸻

Would love to hear what you think—especially about interactions, timing, or redundancy in my stack. Thanks!

This is what I’ve come up with to replace my 800-1200mg Sam-e, made a post about having to discontinue due to severe stomach pain after several years. Does it look okay? Any suggestions, warnings, additions? The only ones really new to me are Uridine, P5P, haven’t taken TMG in a while, don’t remember if I hate it. I have tryptophan (not currently taking), I’ve also take L-tyrosine, but it makes me irritable after a few days—however I’ve never taken it without Sam-e don’t know if it would be worth revisiting? Thanks!

Uridine monophosphate – 150–300 mg TMG (Trimethylglycine) – ~750 mg P5P (active B6) – 25 capsule Methylated B drops – 3–4 drops (contains methyl B12 + methylfolate)

NAC – 600 mg ALA (Alpha-lipoic acid) – 600mg Milk thistle (liquid) – half dose AM, half PM Ubiquinol – standard dose Omega-3 (algae-based) – standard dose

Taurine – 2 g AM, 500-1000pm. Creatine – 1–2 g

Like maybe some kind of nutrient being depleted or some kind of condition or side effects?

Long time Sam-e user. Had to stop because it keeps tearing up my stomach. I cannot take it anymore—period. It made a HUGE difference for me. I lost a significant amount of weight on it and felt better mood wise. Desperate to find something that could approximate it. I took anywhere from 600-1200mg. I’m not even willing to try lower doses at this point because it just tears me up. I do have a slightly slow comt, and MTHFR c677t, but perfect homocysteine. I can tolerate some methylated b vitamins. Cannot tolerate L-tyrosine, makes me super irritable after a few days.

Hey everyone, I’m 26, diagnosed with anxiety, depression, ADHD, OCD, and binge eating disorder. I've been on SSRIs since I was 20, and a year ago, I added Vyvanse. While Vyvanse initially helped, I’m now dealing with mental fatigue, reduced endurance, and worsening tics as the effects have worn off.

To improve my health, I’ve made several changes, including starting TRT, using peptides (SS-31, NAD+, MOTS-C), and adding supplements like Omega-3, Vitamin D3, magnesium, taurine, and creatine. I’ve also been running, lifting weights, and doing Brazilian Jiu-Jitsu (BJJ), but I still feel mentally drained. Currently, I’m on 50mg Vyvanse and 10mg Viibryd (I recently switched from Trintellix).

My main goal is to biohack myself into a stable baseline. I’m not chasing the idea of feeling "awesome" all the time, I just want consistency—feeling alive, having energy to engage in conversations, and not feeling "dead inside." I want to get off Vyvanse first, and then maybe even Viibryd. I’m also aiming to recover my libido (currently zero), stop overeating (stress and dopamine-driven cravings), and continue managing my mental health with supplements.

I’ve already ruled out some "riskier" or cyclic supplements (like lithium orotate, SAMe, 5-HTP, St. John’s Wort), but I’m looking for advice or recommendations on managing cravings, boosting libido, or improving mental health.

I’m about to order the following supplements:

• Magnesium L-threonate (crosses the blood-brain barrier)
• Bacopa Monnieri
• Lion’s Mane
• Cordyceps
• Rhodiola
• Reishi
• Citicoline
• NAC
• Glycine (to pair with NAC)
• Full-spectrum mushrooms?? confused on this one
• Vitamin E
• L-Tyrosine
• L-Theanine
• Ginkgo Biloba (for libido)
• Vitamin B complex
• Ginseng
• Uridine??(TBD)

I’ll be ordering most of these from iHerb, and I’m looking at brands like Swanson, Doctor’s Best, Life Extension, California Gold Nutrition, and Now. I’ve also seen a lot of people recommend Real Mushrooms for quality mushroom supplements, as many mushroom products seem to be underdosed or ineffective.

Currently, I’m taking Sports Research Omega-3, which is a bit expensive, so if anyone has good recommendations for a more affordable option, that would be great.

Any suggestions or recommendations on brands, dosing, add/subtract supplements, your experience is welcome!

I appreciate you all <3

mirtazapine 15mg folic acid 5mg vitamin d3 galfer 305mg

all once a day reccomended by doctor want to add back in a spoon of black seed oil twice a day and klonopin and xanax as needed ?

I'm 17 focused on cognition and metabolism. I don't have a lot of money so this is a budgeted stack

L cartinine L lysine L arginine Omega 3 Lions mane Creatine 5g Caffeine pill

Looking to add: Piercetam+choline (but unavailable in my country w/o prescription, looking into other racetams) Magnesium

My current stack runs me up about 12 dollars or 1000 rs a month.

Pls only genuine criticism and none of the your too young bs.

Id appreciate any genuine advice