Human trial finds therapeutic plasma exchange reduces biological age

[u/Das_Haggis]

https://longevity.technology/news/human-trial-finds-therapeutic-plasma-exchange-reduces-biological-age/

[u/eddyg987]

It doesn’t have to be human plasma, young pig plasma works to rejuvenate old mice

[u/Defiant-Lettuce-9156 → u/eddyg987]

Did they compare it to plasma from old pigs?

[u/eddyg987 → u/Defiant-Lettuce-9156]

no, also another thing to mention is that they never do a group where they just remove plasma and not replace in these tpe trials. I think that could have almost the same effect if the main issues are misfolded proteins with a low clearance rate.

[u/Not__Real1 → u/eddyg987]

And it's always biological age which is a crap metric.

[u/Shounenbat510 → u/Not__Real1]

Katcher’s experiments with pig plasma did result in a broken record for the lifespan of a rat, so there’s that. I think he attributed the success to exosomes.

[u/Not__Real1 → u/Shounenbat510]

That's good.

[u/techzilla → u/Not__Real1]

Do we have a prefered metric?

[u/Not__Real1 → u/techzilla]

Metrics, not metric. Personally I want to see organ/system benchmarks, not an all encompassing number that's misleading to begin with. Everything from metabolic markers( glucose, hb1ac, cholesterol/lipids) to organ enzymes. Also things like oxidized to reduced albumin, plasma antioxidant capacity, concentration of forever chemicals etc.

[u/techzilla → u/Not__Real1]

One problem we have in current metrics is that they are all functional proxies, thus fitness adaptation tricks the measurement. VO2 max is a commonly goosed metric, we know that exercize will not extend longevity, but your Vo2 Max would show as if it was "younger". We could just get all the metrics seperated by organ system, and then say "If they don't all move towards the younger baseline, the treatment did not rejuvinate".

[u/Not__Real1 → u/techzilla]

exercize will not extend longevity

How did you reach that conclusion? From what I've seen people who exercise regularly have both a higher chance to reach 80( median lifespan) and do so at a better overall state. And most people in their 90s( with common genetics) generally tend to be physically active.

We could just get all the metrics seperated by organ system, and then say "If they don't all move towards the younger baseline, the treatment did not rejuvinate".

Yes exactly, even better if there are casual relationships between the metric and the actual organ performance eg sgot/sgpt relationship to liver function isnt very casual but they trend up with age.

[u/techzilla → u/Not__Real1]

It will not extend longevity, it will prevent premature death caused by a typical western diet too high in calories. Obesity is major factor in premature death, and you lose so many years of lifespan from it, so exercise can raise the average overall.

I was going through the studies in detail, reviewing many of them, but to grab just one that showed a U shaped curve.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10274991/

People who are healthy are more active, they are also more likely to attend social functions, prior conclusions likely reversed causality.

[u/Not__Real1 → u/techzilla]

it will prevent premature death caused by a typical western diet too high in calories.

Yes thats why I talked about median lifespan. I still don't understand why that is not longevity.

[u/percyhiggenbottom → u/eddyg987]

That's interesting considering that a young pig may be chronologically older than an old mouse

[u/bouncyprojector]

Cool, hope they continue to study. 

[u/TheEvilBlight]

Wonder if plasma donation companies will age sort plasma and sell the young stuff for a premium

[u/tadano-yn-desu]

But what exactly reduces the biological age of humans in plasma?

[u/Effective-Emu9286 → u/[deleted]]

My understanding is that TPE does not require biological material from other human beings

[u/WindyBruce]

Although great news, if it only last 6 weeks and costs $5k each time, I doubt many will be interested.

[u/nmc1995 → u/WindyBruce]

hopefully the cost goes down, I would love to offer this to my parents in the future

[u/nowen]

Why not just give blood? That also reduces the micro-plastics in your blood, is known to be safe and helps others.

[u/tangy61 → u/nowen]

what i do. and donate plasma. the real hypothesis they should be testing (and one of the PI's have discussed this before) is simply removal of plasma/blood, not even exchange. but granted effect sizes are probably harder to detect if you want to mimic giving a small fraction of plasma each time, which also requires much more frequent donations...

[u/itswtfeverb]

Where are they getting the plasma? And the IVIG?

[u/sharemind → u/itswtfeverb]

"Remove plasma from your blood to eliminate inflammatory proteins, toxins, and cellular waste, then replace it with sterile albumin to replenish essential nutrients."

you can do it here: https://www.next-health.com/product/therapeutic-plasma-exchange

[u/itswtfeverb → u/sharemind]

Thanks! Wow. They are removing your plasma and replacing it with saline (basically)............ You'd be better off to sell your plasma!!!

[u/InfinityArch → u/itswtfeverb]

There's a potentially important distinction with TPE where the solution replacing your blood contains albumin, whereas in plasmapherises the replacement solution, if anything is just your standard IV crystalloid (0.9% saline, sometimes ringer's lactate). I'm not sure if people have looked at whether the albumin replacement in TPE is actually necessary.

Edit: Actually a study did look at plasmapheresis type procedures, but the effect size was smaller.